People you have severed ties with. ( Hostile witnesses ? )

If you have severed ties with people who you once knew well and have even lived with but have since moved on and don’t have contact with now but you consider them as potential hostile witnesses, can this admission be prejudicial to your application for a security clearance ?

Maybe if you haven’t lived with them for over 10-15 years, it might not matter much. I guess it depends how far back the background check goes for places you have lived.