If you elect to self-cancel your COE, then you can reapply and will likely get another chance at candidacy for the same or similar position, assuming there are no red flags by the time your next application is submitted. This dynamic changes out of the applicant’s favor as soon as the IC organization takes negative action(s) against the applicant, e.g., suitability denials, clearance denials, etc. Some IC orgs will take negative action and still tell the applicant to reapply after X number of months/years. Other IC orgs are finicky and won’t, essentially blackballing the applicant from that specific organization. Of course, there are always exceptions.